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cd146  (OriGene)


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    Structured Review

    OriGene cd146
    Figure 1. Representative IHC images of <t>CD146,</t> survivin and Ki‑67 expression. Expression of CD146 in epithelioid MPeM: (A) Negative; (B) 1+; (C) 2+; (D) 3+. Expression of CD146 in non‑epithelioid MPeM: (E) Negative; (F) 1+; (G) 2+; (H) 3+. Expression of survivin in epithelioid MPeM: (I) Negative; (J) 1+; (K) 2+; (L) 3+. Expression of survivin in non‑epithelioid MPeM: (M) Negative; (N) 1+; (O) 2+; (P) 3+. Expression of Ki‑67 in epithelioid MPeM: (Q) Lower expres- sion; (R) higher expression. Expression of Ki‑67 in non‑epithelioid MPeM: (S) Lower expression; (T) higher expression. Staining of CD146 was observed in the cytoplasm and cell membrane, staining of survivin was found in the nucleus and cytoplasm, while Ki‑67 staining was nuclear. Magnification, x400. IHC, immunohistochemistry; MPeM, malignant peritoneal mesothelioma.
    Cd146, supplied by OriGene, used in various techniques. Bioz Stars score: 90/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/primary+antibodies+cd146+clone+ep54/CD146+(MCAM)+Rabbit+Polyclonal+Antibody/pm32382335-78-27-34
    Average 90 stars, based on 2 article reviews
    cd146 - by Bioz Stars, 2026-09
    90/100 stars

    Images

    1) Product Images from "Survivin expression as an independent predictor of overall survival in malignant peritoneal mesothelioma."

    Article Title: Survivin expression as an independent predictor of overall survival in malignant peritoneal mesothelioma.

    Journal: Oncology letters

    doi: 10.3892/ol.2020.11505

    Figure 1. Representative IHC images of CD146, survivin and Ki‑67 expression. Expression of CD146 in epithelioid MPeM: (A) Negative; (B) 1+; (C) 2+; (D) 3+. Expression of CD146 in non‑epithelioid MPeM: (E) Negative; (F) 1+; (G) 2+; (H) 3+. Expression of survivin in epithelioid MPeM: (I) Negative; (J) 1+; (K) 2+; (L) 3+. Expression of survivin in non‑epithelioid MPeM: (M) Negative; (N) 1+; (O) 2+; (P) 3+. Expression of Ki‑67 in epithelioid MPeM: (Q) Lower expres- sion; (R) higher expression. Expression of Ki‑67 in non‑epithelioid MPeM: (S) Lower expression; (T) higher expression. Staining of CD146 was observed in the cytoplasm and cell membrane, staining of survivin was found in the nucleus and cytoplasm, while Ki‑67 staining was nuclear. Magnification, x400. IHC, immunohistochemistry; MPeM, malignant peritoneal mesothelioma.
    Figure Legend Snippet: Figure 1. Representative IHC images of CD146, survivin and Ki‑67 expression. Expression of CD146 in epithelioid MPeM: (A) Negative; (B) 1+; (C) 2+; (D) 3+. Expression of CD146 in non‑epithelioid MPeM: (E) Negative; (F) 1+; (G) 2+; (H) 3+. Expression of survivin in epithelioid MPeM: (I) Negative; (J) 1+; (K) 2+; (L) 3+. Expression of survivin in non‑epithelioid MPeM: (M) Negative; (N) 1+; (O) 2+; (P) 3+. Expression of Ki‑67 in epithelioid MPeM: (Q) Lower expres- sion; (R) higher expression. Expression of Ki‑67 in non‑epithelioid MPeM: (S) Lower expression; (T) higher expression. Staining of CD146 was observed in the cytoplasm and cell membrane, staining of survivin was found in the nucleus and cytoplasm, while Ki‑67 staining was nuclear. Magnification, x400. IHC, immunohistochemistry; MPeM, malignant peritoneal mesothelioma.

    Techniques Used: Expressing, Staining, Membrane, Immunohistochemistry

    Figure 2. Survivin (A) CD146 (C) and Ki‑67 (E) expression is absent in normal mesothelium. Survivin (B) CD146 (D) and Ki‑67 (F) expression is absent in peritonitis specimens (B, D, F). Magnification x400.
    Figure Legend Snippet: Figure 2. Survivin (A) CD146 (C) and Ki‑67 (E) expression is absent in normal mesothelium. Survivin (B) CD146 (D) and Ki‑67 (F) expression is absent in peritonitis specimens (B, D, F). Magnification x400.

    Techniques Used: Expressing

    Figure 4. Kaplan‑Meier survival curves for different predictors. (A) Ki‑67 grade 2 expression; (B) CD146 grade 4 expression; (C) survivin grade 4 expression; (D) forest plot of disease‑free survival hazard ratios of major subgroups (exploratory analysis). Dashed lines represent median survival. PCI, peritoneal cancer index. Treatment protocols 0, best supportive care; Treatment protocols 1, intraperitoneal chemotherapy; Treatment protocols 2, systemic chemotherapy. *P<0.05. ***P<0.001.
    Figure Legend Snippet: Figure 4. Kaplan‑Meier survival curves for different predictors. (A) Ki‑67 grade 2 expression; (B) CD146 grade 4 expression; (C) survivin grade 4 expression; (D) forest plot of disease‑free survival hazard ratios of major subgroups (exploratory analysis). Dashed lines represent median survival. PCI, peritoneal cancer index. Treatment protocols 0, best supportive care; Treatment protocols 1, intraperitoneal chemotherapy; Treatment protocols 2, systemic chemotherapy. *P<0.05. ***P<0.001.

    Techniques Used: Expressing

    Related Articles

    Incubation:

    Article Title: Survivin expression as an independent predictor of overall survival in malignant peritoneal mesothelioma.
    Article Snippet: .. Specimens were incubated overnight at 4 ̊C with primary antibodies against the following molecules: Survivin (dilution, 1:100; rabbit monoclonal, clone EP119; OriGene Technologies, Inc.; cat. no. S1130), CD146 (dilution, 1:100; rabbit monoclonal, clone EP54; OriGene Technologies, Inc.; cat. no. GTX34461) and Ki-67 (dilution, 1:200; rabbit monoclonal, clone EP5; OriGene Technologies, Inc.; cat. no. GTX16667). .. After incubation (at room temperature for 40 min) with peroxidase-conjugated secondary antibodies (diluted concentration 1:200; Santa Cruz Biotechnology, Inc.), a Diaminobenzidine Peroxidase Substrate kit (Laboratories, Inc.) was used to visualise signals (light microscope; magnification, x43; Olympus Corporation, put in multiple x10).



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